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3 edition of Toxicological profile for 4,4"-methylenebis(2- chloroaniline)(MBOCA) found in the catalog.

Toxicological profile for 4,4"-methylenebis(2- chloroaniline)(MBOCA)

Toxicological profile for 4,4"-methylenebis(2- chloroaniline)(MBOCA)

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Published by U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry in [Atlanta, GA] .
Written in

    Subjects:
  • Methylamines -- Toxicology,
  • Methylamines -- Physiological effect,
  • Methylamines -- Environmental aspects

  • Edition Notes

    Statementprepared by Clement International Corporation.
    SeriesToxicological profile for, TP -- 93/12., TP (Series) (Atlanta, Ga.) -- 93/12.
    ContributionsClement International Corporation., United States. Agency for Toxic Substances and Disease Registry.
    The Physical Object
    Paginationxvii, 129 p. in various pagings :
    Number of Pages129
    ID Numbers
    Open LibraryOL18715887M
    OCLC/WorldCa31494667

    Acetone. Definition: CAS Acetone is a manufactured chemical that is also found naturally in the environment. It is a colorless liquid with a distinct smell and taste. It evaporates easily, is flammable, and dissolves in water. It is also called dimethyl ketone, 2-propanone, and beta-ketopropane.


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Toxicological profile for 4,4"-methylenebis(2- chloroaniline)(MBOCA) Download PDF EPUB FB2

For Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for 4,4'-Methylenebis (2-Chloroaniline) (MBOCA). Public Health Service, U. Department of Health and Human Services, Atlanta, GA. Department of Health and Human Services.

Hazardous Substances Data Bank (HSDB, online database). 4,4'- METHYLENEBIS (2-CHLOROANILINE) CAS: Division of Toxicology May This Public Health Statement is the summary chapter from the Toxicological Profile for 4,4'-Methylenebis (2-chloroaniline) (MBOCA).

It is one in a series of Public Health Statements about hazardous substances and their health effects. Toxicological profile for 4,4'-methylenebis(2­ chloroaniline) (MBOCA). Atlanta, GA: U.

Department of Health and Human Services, Public Health Service. Federal Recycling Program Printed on File Size: KB. The HEAST (U. EPA, ) includes subchronic and chronic oral RfDs of 7E-4 mgkg-day for 4,4'-methylenebis(2-chloroaniline) (MOCA) that were based on liver and urinary bladder effects in dogs given an average daily dose of mgkg-day of MOCA via gelatin capsules for 9 years by Stula et al.

ATSDR () Toxicological Profile for 4,4-Methylenebis(2-chloroaniline) (MBOCA). The US Agency for Toxic Substances and Disease Registry, Available: tppdf.

NTP () Notice of Availability of 10th Report on Carcinogens. National Toxicology Program, 67, Cited by: 1. 4,4'-Methylene bis (2-chloroaniline) | OEHHA. Home. Proposition Chemicals Considered or Listed Under Proposition AEROBIC: 4,4'-methylenebis(2-chloroaniline), present at mgL, reached 0 of its theoretical BOD in 8 weeks using an activated sludge inoculum at 30 mgL in the Japanese MITI test(1).

4,4'-Methylenebis(2-chloroaniline) was not degraded after 6 weeks in a static system in which 2 mgL of the compound was seeded with sludge, incubated for 7. The concentration of 4,4'-Methylenebis (2-Chloroaniline) found in fish tissues is expected to be somewhat higher than the average concentration of 4,4'-Methylenebis (2-Chloroaniline) in the water from which the fish was taken.

It can become concentrated in the root fibres of plants grown in soil that contains the compound. Year book of pulmonary disease: Amercian journal of public health (voulme 61) Toxicological profile for 2,4-and 2,6- dintrotoluene: Toxicological profile for 4,4'-methylenebis (2-chloroaniline) Oct Toxicological profile for chlorobenzofurans.

Preferred SDS: View Hazards identification Classification of the substance or mixture: GHS Classification in accordance with 29 CFR (OSHA HCS) None found. France 4: 3 ATSDR () Toxicological profile for 4, 4-methylenebis (2-chloroaniline) (MBOCA).

The US Agency for Toxic Substances and Disease Registry. 4 Chen HI, Liou SH, Loh CH, Uang SN, Yu YC, et al.

() Bladder cancer screening and monitoring of 4,4-methylenebis. Toxicological profile for 4,4-Methylenebis-(2-chloroaniline) (MBOCA). Publication No. TP Agency for Toxic Substances and Disease Registry, Atlanta, Toxicological profile for 4,4-methylenebis book. 1,1-methylene bis (4-isocyanatocyclohexane) is a clear colorless to light-yellow liquid.

(NIOSH, ) CAMEO Chemicals. Dicyclohexylmethane-4,4'-diisocyanate is a diisocyanate consisting of dicyclohexylmethane with two isocyanate groups at the 4- and 4'-positions.

It has a role as an allergen. NIOSH. At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF 10,) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.

(APF 10,) Any supplied-air respirator that has a full facepiece and is operated in a. Exposure to 4,4'-methylenebis(2-chloroaniline) MBOCA) happens mostly in the workplace by touching it or by breathing contaminated air. MBOCA is suspected of causing bladder cancer in people and animals.

This chemical has been found in at least 4 of 1, National Priorities List sites identified by the Environmental Protection Agency. 4,4'-Methylenebis(2-methylaniline) | C15H18N2 | CID - structure, chemical names, physical and chemical properties, classification, patents, literature. 4,4-Methylenebis(2-chloroaniline) (MBOCA) is a probable human carcinogen.

Few studies have been performed regarding the genotoxicity of MBCOA, and the MBOCA metabolic pathway is not fully understood. We treated four-week-old ICR male mice weighing 25 - 30 g with MBOCA and observed the effects of MBOCA on the internal organs.

It can be concluded that MBOCA is a carcinogen and also. Toxicological profile for 4,4-Methylenebis(2-chloroaniline) (MBOCA). Agency for Toxic Substances and Disease Registry, public health service, U. Department of Health and Human Services, Atlanta, GA. Google Scholar.

From until hospital admission inthe patient had worked in a company that produced the 4,4 -methylenebis(2-chloroaniline) (MBOCA) curing agent.

He did not wear any personal protective. stream tobacco smoke. 4-Methylimidazole was nomi-nated by the National Cancer Institute for a long-term study because of the high potential for human exposure.

Male and female FN rats and B6C3F 1 mice were exposed to 4-methylimidazole ( pure) in feed for 2 years. Fifteen-day and week toxicity studies of 4-methylimidazole in FN. Purchase Certified Reference Standards from AccuStandard.

Order 4,4'-Methylenebis(2-chloroaniline) as Catalog No.   Introduction. 4,4-Methylenebis(2-chloroaniline) (MBOCA) is a synthetic aromatic amine used in industry primarily to produce castable polyurethane parts (U.

Department of Health and Human Services, ). Although MBOCA is considered likely to be carcinogenic to humans by the International Agency of Research on Cancer (), we reported a sentinel case of urinary bladder cancer found in one.

1) 4,4'-Methylenebis(2-chloroaniline), or MBOCA, is primarily used in the production of solid elastomeric is used as a curing agent for polyurethanes, isocyanate-containing polymers, and epoxy resin bonding systems.

MBOCA is also employed in the manufacture of crosslinked urethane foams used in automobile seats and safety padded dashboards. Dicyclohexylmethane 4,4'-diisocyanate, DMDI, HMDI, Hydrogenated MDI, bis(4-Isocyanatocyclohexyl)methane, Reduced MDI, Saturated MDI CAS No.

RTECS No. NQ DOT ID Guide. Formula. CH[(CH)NCO]. Reactivity Profile. 4,4'-METHYLENEBIS (2-CHLOROANILINE) is a weak base. Undergoes an exothermic and self-sustaining decomposition reaction when exposed to heat above °F, In a closed container, the pressure buildup can be rapid enough to cause an explosion.

PMID ; American journal of industrial medicine Dec; 57 (12) Name matches: triethylenetetramine 2,2'-dimethyl-4,4'-methylene-bis (cyclohexylamine) Occupational allergic contact dermatitis caused by 2,4,6-tris- (dimethylaminomethyl)phenol, and review.

For MBOCA, "There is inadequate evidence in humans for the carcinogenicity of 4,4'-methylenebis(2-chlorobenzenamine). " However, "Particularly compelling data on the genotoxicity of MOCA include the higher micronucleus frequencies measured in exfoliated bladder epithelial cells and in peripheral lymphocytes of exposed workers.

4,4-Methylenebis(2-chloroaniline) (MBOCA) is an aromatic diamine used as a curing agent for polyurethane and epoxy resins. It has several of the general toxicity characteristics of aromatic amines and is most likely a human carcinogen.

Methaemoglobinemia and the resultingcyanosis, which are hallmark symptoms of exposure. Bioaccumulation Estimates from Log Kow (BCFWIN v): Log BCF from regression-based method (BCF ) log Kow used: (estimated) Volatilization from Water: Henry LC: E atm-m3mole (estimated by Group SAR Method) Half-Life from Model River: E hours (E days) Half-Life from Model Lake: E hours (9.

Toxicological Profile for Chlorophenols Centers for Disease Control. Dept. of Health and Human Services. Lamb JC. Neoplastic response of F rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'4'-oxydianiline, and 4,4'4'-methylenedianiline.

Buy Softcover Book. 4,4'-Methylenebis (2,6-diethylaniline) is a white to brown crystaline powder, insoluble in water. It provides improved mechanical and dynamic properties, so it is an excellent chain extender for polyurethanes and a curing agent for epoxides.

It is used as a precursor for polyimides and as an intermediate for organic syntheses. Likewise, the Group-1 classification of 4,4ʹ-methylenebis(2-chloroaniline) was based on sufficient evidence of carcinogenicity in experimental animals and strong mechanistic evidence, indicating that the toxicological profile of this genotoxic amine is similar to that of ortho-toluidine (a re-affirmed Group-1 carcinogen), that it forms DNA.

4,4-Methylene-bis(2-chloroaniline) (MOCA) is an aromatic amine used widely in industry, and human exposure to this compound is well documented. MOCA induces lung and liver tumors in rodents and urinary bladder tumors in dogs, and it is regarded as a suspect urinary.

The 4,4'-bipyridine mol-ecule is disordered over two positions in a ratio. In the crystal, the 2-meth-oxy-benzoic acid and 4,4'-bipyridine mol-ecules are connected by inter-molecular O-HN hydrogen bonds. The dihedral angle between the carboxy group and its attached ring is (2)°.

4,4'-Methylenebis(2-chloroaniline), or MBOCA, is primarily used in the production of solid elastomeric parts. It is used as a curing agent for polyurethanes, isocyanate-containing polymers, and epoxy resin bonding systems.

MBOCA is also employed in the manufacture of crosslinked urethane foams used in automobile seats and safety padded dashboards. Evidence that a beta-n-glucuronide of 4,4'-methylene-bis(2-chloroaniline) (MBOCA) is a major urinary metabolite in man: implications for biological monitoring.

Br J Ind Med Ducos P, Maire C, Gauidin R. Assessment of occupational exposure to 4,4'-methylenebis(2-chloroaniline) (MOCA) by a new sensitive method for biological. 4,4'-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production.

MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder carcinogen. A Toxicological Profile for Ethylbenzene was released in September This edition supersedes any previously released draft or final profile.

Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at. Methylene diphenyl diisocyanate (T3D) Methylene diphenyl diisocyanate, also know as MDI, is a chemical compound of cyanide and an aromatic diisocyanate.

It is used in the manufacture of polyurethane and as an an industrial strength adhesive. (5). belongs to the class of organic compounds known as diphenylmethanes.

VIM could be quaternized by 1,4-phenylene bis(4-bromobutanoate) or 1,6-hexanediol bis(2-bromopropionate), leading to the formation of degradable cross-linking network and ionic microgels.

4,4'-Methylenebis[2, 6-bis(hydroxymethyl) phenol] SMILES. c1c(cc(c(c1CO)O)CO)C c2cc(c(c(c2)CO)O)CO Copy. Std. InChi. InChI=1S/C17H20O6/c1 (( 9)16(12)22) ()17(23)15() /h,H,1,H2 Copy. Std. InChIKey. MWPXMEJTTYFHGR-UHFFFAOYSA-N Copy.

Cite this record.immune-related cellular effects at lower doses, including increased IgG1, IL-4, and various splenocyte T-cell populations at doses more than 6 times higher than the subchronic RfD. Inconsistent results have been reported for IgG2a, interferon -ɣ, and splenic cell numbers.

These low dose cellular-level effects. Compared with these iconic chemicals, the polyurethane curative 4,4´-methylenebis 2-chloroaniline, also known as MOCA or MbOCA, is much more obscure. But it .